Recent insights into the pathogenesis of bacterial sepsis.

Bacterial Etiology and Antibiotic Sensitivity Patterns of Early-Late Onset Neonatal Sepsis among Newborns in Shiraz, Iran 2004-2007

Background: Neonatal sepsis is a major cause of mortality and morbidity, especially in developing countries. The goal of the present study was to determine the bacterial etiology and antibiotic sensitivity patterns of neonatal sepsis. Methods: This cross sectional study was conducted on 208 neonates admitted with clinically suspected sepsis over a period of 30 months. Sepsis was divided into ea...

Insights into early mycobacterial pathogenesis from the zebrafish.

Here we discuss the application of the zebrafish as a relatively new model host for the study of mycobacterial pathogenesis. Recent advances in our understanding of host-mycobacteria interactions from the zebrafish include insights into the role of the innate immune system in both controlling and facilitating infection. Analysis in the zebrafish has revealed that innate macrophages restrict ini...

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone

BACKGROUND: Canine low-dose sepsis model provides a reliable setting to study innovative drugs. Li- popolysaccharides (LPS), a major constituent of bacterial outer membrane, have been demonstrated to play a critical role in the initiation of pathogenesis. Lipopolysaccharide-induced sepsis has been extensively studied in laboratory animals; but its importance has mainly remained...

Insights into the autistic disorder and potential therapeutic approaches

Autism and autism spectrum disorders (ASDs) such as Rett syndrome and Asperger syndromeare enigmatic and complex neurodevelopmental disorders, thought to have originated inparticular interactions of genetic and environmental factors. Despite the extensive research,exact mechanism of pathogenesis is not still completely understood. ASDs are characterizedby deficits and abnormalities in communica...